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Onderzoek: biologische reacties op asbestvezels

18-10-2005 00:00

Bhattacharya en collega's beschrijven in dit overzichtsartikel het totaal aan biologische reacties in het lichaam nadat iemand aan asbest is blootgesteld. Onderscheid wordt gemaakt naar indicatoren van (1) blootstelling (reacties op vezels), (2) effect (ziekte) en (3)kwetsbaarheid (verschillen tussen individuen en/of populaties). Bron: Bhattacharya K, Dopp E, Kakkar P, Jaffery FN, Schiffmann D, Jaurand MC, Rahman I, Rahman Q. (2005). Biomarkers in risk assessment of asbestos exposure. Mutation Research, Aug 17, article in press.
Bhattacharya K, Dopp E, Kakkar P, Jaffery FN, Schiffmann D, Jaurand MC, Rahman I, Rahman Q. (2005). Biomarkers in risk assessment of asbestos exposure. Mutation Research, Aug 17, article in press. 9: Mutat Res. 2005 Aug 17. [Epub ahead of print]

Abstract


Developments in the field of molecular epidemiology and toxicology have given

valuable tools for early detection of impending disease or toxic condition.

Morbidity due to respiratory distress, which may be due to environmental and

occupational exposure, has drawn attention of researchers worldwide. Among the

occupational exposure to respiratory distress factors, fibers and particles have

been found to be main culprits in causing diseases like asbestosis, pleural

plaques, mesotheliomas and bronchogenic carcinomas. An early detection of the

magnitude of exposure or its' effect using molecular end points is of growing

importance. The early inflammatory responses like release of the inflammatory

cells collected by non-invasive methods give an indication of the unwanted

exposure and susceptibility to further complications. Since free radicals like

O(2)(-), OH, OOH, NO, NOO, etc. are involved in the progression of

asbestos-related diseases and lead to cytogenetic changes, an evaluation of

antioxidant states reducing equivalents like GSH and ROS generation can be a

good biomarker. The cytogenetic end points like chromosomal aberration,

micronucleus formation and sister chromatid exchange give indication of genetic

damage, hence they are used as effective biomarkers. New techniques like

fluorimetric analysis of DNA unwinding, alkaline elution test, fluorescent in

situ hybridization and comet assay are powerful tools for early detection of

initiation of disease process and may help in planning strategies for minimizing

morbidity related to asbestos fiber exposure. The present review article covers

in detail possible biomarkers for risk assessment of morbidity due to

fibers/particles in exposed population.